The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 18, 2022
Filed:
Aug. 06, 2020
Applicant:
The National Institute for Biotechnology IN the Negev Ltd., Beer-Sheva, IL;
Inventors:
Varda Shoshan-Barmatz, Omer, IL;
Arie Lev Gruzman, Tzur Hadassah, IL;
Assignee:
THE NATIONAL INSTITUTE FOR BIOTECHNOLOGY IN THE NEGEV LTD., Beer-Sheva, IL;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 241/04 (2006.01); C07D 211/66 (2006.01); A61P 25/28 (2006.01); C07D 491/04 (2006.01); A61P 25/16 (2006.01); C07D 403/04 (2006.01);
U.S. Cl.
CPC ...
C07D 241/04 (2013.01); A61P 25/16 (2018.01); A61P 25/28 (2018.01); C07D 211/66 (2013.01); C07D 403/04 (2013.01); C07D 491/04 (2013.01);
Abstract
Provided herein piperazine and piperidine derivatives, their synthesis and use thereof in inhibiting VDAC oligomerization, apoptosis and mitochondria dysfunction. Also provided methods of treatment of diseases associated with said processes, e.g. Alzheimer's and Parkinson's diseases.