The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 18, 2022

Filed:

Jun. 26, 2020
Applicant:

University of Utah Research Foundation, Salt Lake City, UT (US);

Inventor:

Russell J. Stewart, Salt Lake City, UT (US);

Assignee:

UNIVERSITY OF UTAH RESEARCH FOUNDATION, Salt Lake City, UT (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61L 24/10 (2006.01); A61L 24/04 (2006.01); A61L 24/00 (2006.01); A61K 49/00 (2006.01); A61L 24/02 (2006.01); C09D 5/16 (2006.01);
U.S. Cl.
CPC ...
A61L 24/046 (2013.01); A61K 49/0043 (2013.01); A61K 49/0054 (2013.01); A61K 49/0073 (2013.01); A61L 24/0015 (2013.01); A61L 24/0031 (2013.01); A61L 24/0042 (2013.01); A61L 24/02 (2013.01); A61L 24/043 (2013.01); A61L 24/10 (2013.01); A61L 24/104 (2013.01); C09D 5/1668 (2013.01); A61L 2300/416 (2013.01); A61L 2300/44 (2013.01); A61L 2430/02 (2013.01); A61L 2430/36 (2013.01);
Abstract

Described herein are fluid complex coacervates that produce solid adhesives in situ. Oppositely charged polyelectrolytes were designed to form fluid adhesive complex coacervates at ionic strengths higher than the ionic strength of the application site, but an insoluble adhesive solid or gel at the application site. When the fluid, high ionic strength adhesive complex coacervates are introduced into the lower ionic strength application site, the fluid complex coacervate is converted to a an adhesive solid or gel as the salt concentration in the complex coacervate equilibrates to the application site salt concentration. In one embodiment, the fluid complex coacervates are designed to solidify in situ at physiological ionic strength and have numerous medical applications. In other aspects, the fluid complex coacervates can be used in aqueous environment for non-medical applications.


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