The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 18, 2022

Filed:

Sep. 18, 2018
Applicants:

Chan Zuckerberg Biohub, Inc., San Francisco, CA (US);

The Board of Trustees of the Leland Stanford Junior University, Stanford, CA (US);

Inventors:

Michael F. Clarke, San Francisco, CA (US);

Robert W. Hsieh, San Francisco, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/02 (2006.01); C07H 21/04 (2006.01); A61K 31/713 (2006.01); A61P 35/00 (2006.01); A61K 45/06 (2006.01); C12N 15/113 (2010.01); G01N 33/574 (2006.01);
U.S. Cl.
CPC ...
A61K 31/713 (2013.01); A61K 45/06 (2013.01); A61P 35/00 (2018.01); C12N 15/113 (2013.01); C12N 2310/14 (2013.01); C12N 2310/531 (2013.01); C12N 2320/30 (2013.01); G01N 33/57415 (2013.01); G01N 2800/52 (2013.01);
Abstract

The invention is directed to methods of treating TNBC in a patient by administering to the patient an agent that inhibits the expression or activity of cyclin-dependent kinase 19 (CDK19). In some embodiments, the agent may be a small molecule inhibitor, a polynucleotide (e.g., shRNA. siRNA), or a protein (e.g., an antibody). In some embodiments, the agent does not inhibit the activity or expression of CDK8.


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