The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 18, 2022

Filed:

Dec. 03, 2015
Applicant:

Ono Pharmaceutical Co., Ltd., Osaka, JP;

Inventors:

Kensuke Kusumi, Osaka, JP;

Haruto Kurata, Osaka, JP;

Atsushi Naganawa, Osaka, JP;

Yasuyo Kodera, Osaka, JP;

Yuichi Inagaki, Ibaraki, JP;

Hiroya Takizawa, Osaka, JP;

Mark Allan Wolf, Delanson, NY (US);

Joseph Raker, Delmar, NY (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/397 (2006.01); A61P 25/28 (2006.01); C07D 205/04 (2006.01); C07D 401/10 (2006.01); C07D 207/16 (2006.01); C07D 403/10 (2006.01); A61K 31/015 (2006.01); A61K 31/19 (2006.01); C07C 13/20 (2006.01); C07C 13/48 (2006.01);
U.S. Cl.
CPC ...
A61K 31/397 (2013.01); A61K 31/015 (2013.01); A61K 31/19 (2013.01); A61P 25/28 (2018.01); C07C 13/20 (2013.01); C07C 13/48 (2013.01); C07D 205/04 (2013.01); C07D 207/16 (2013.01); C07D 401/10 (2013.01); C07D 403/10 (2013.01); C07C 2602/10 (2017.05);
Abstract

A compound represented by general formula (I) wherein all the symbols are as defined in the specification has a selective S1P5 receptor agonist activity due to having a linker from a phenyl group to a cyclic substituent in a dihydronaphthalene skeleton; i.e., due to having a short linker of one atom or less as L in general formula (I), and can therefore serve as an agent for treating S1P5-mediated disease, e. g., neurodegenerative disease such as schizophrenia.


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