The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 11, 2022

Filed:

Dec. 18, 2017
Applicant:

Health Research, Inc., Buffalo, NY (US);

Inventors:

Robert A. Fenstermaker, Amherst, NY (US);

Michael J. Ciesielski, Orchard Park, NY (US);

Assignee:

Health Research, Inc., Buffalo, NY (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/50 (2006.01); A61K 39/00 (2006.01); A61K 9/127 (2006.01);
U.S. Cl.
CPC ...
G01N 33/5076 (2013.01); A61K 9/127 (2013.01); A61K 39/00115 (2018.08); G01N 33/502 (2013.01); G01N 2800/52 (2013.01); G01N 2800/54 (2013.01); G01N 2800/7028 (2013.01);
Abstract

Provided is a method for evaluating the progression of glioma in an individual comprising monitoring the levels of circulating exosomes that are positive for survivin and a glial marker (such as glial fibrillary acidic protein). An increase in the level of such exosomes is indicative of poor prognosis. Levels of circulating exosomes that are positive for survivin and glial marker can also be used for evaluating the efficacy of a therapy for glioma in an individual, and modifying the therapy or introducing additional therapy if levels of such exosomes are found to be increasing.


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