The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 11, 2022
Filed:
Dec. 30, 2016
Applicant:
Cedars-sinai Medical Center, Los Angeles, CA (US);
Inventors:
Joshua Breunig, Los Angeles, CA (US);
Moise Danielpour, Los Angeles, CA (US);
Gi Bum Kim, North Hollywood, CA (US);
Assignee:
Cedars-Sinai Medical Center, Los Angeles, CA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/85 (2006.01); A01K 67/027 (2006.01); A61K 48/00 (2006.01); A61K 49/00 (2006.01); C12N 9/22 (2006.01); C12N 15/11 (2006.01);
U.S. Cl.
CPC ...
C12N 15/8509 (2013.01); A01K 67/0275 (2013.01); A61K 48/0066 (2013.01); A61K 49/0008 (2013.01); C12N 9/22 (2013.01); C12N 15/11 (2013.01); A01K 2217/07 (2013.01); A01K 2227/105 (2013.01); A01K 2267/0331 (2013.01); C12N 2015/8572 (2013.01); C12N 2310/20 (2017.05); C12N 2800/80 (2013.01); C12N 2830/50 (2013.01);
Abstract
Described herein are donor vectors and systems for use in in vivo dual recombinase-mediated cassette exchange. Also described are animal models for consistent, rigorous, and facile investigation of transgene expression. Further described are methods of screening for therapeutic drugs using these animal models, and methods of treatment.