The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 11, 2022

Filed:

Jan. 09, 2019
Applicant:

Pneumagen Ltd, Fife, GB;

Inventors:

Helen Connaris, Fife, GB;

Jane Alexandra Potter, Fife, GB;

Assignee:

Pneumagen Ltd, Fife, GB;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/315 (2006.01); A61K 38/00 (2006.01); A61K 39/39 (2006.01); C07K 14/28 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/3156 (2013.01); A61K 38/00 (2013.01); A61K 39/39 (2013.01); C07K 14/28 (2013.01); A61K 2039/55516 (2013.01);
Abstract

The present disclosure a cohort of sialic acid binding molecules which comprise one or more modified carbohydrate binding modules (CBMs). The modified CBMs reduce the risk of adverse events related to the host immune response and/or the production of anti-drug antibodies (ADAs). The modified CBMs can be used in therapy or as medicaments and find specific application as molecules for the modulation of an immune response and/or cell growth. The modified CBMs may also be used as adjuvants, for example mucosal adjuvants and in the treatment and/or prevention of cancer, sepsis and/or diseases caused or contributed to by a pathogen that binds cell surface sialic acid-containing receptors.


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