The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 11, 2022

Filed:

May. 07, 2018
Applicants:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Wen-lian Wu, Green Brook, NJ (US);

Jongwon Lim, Lexington, MA (US);

Jared N. Cumming, Winchester, MA (US);

Benjamin Wesley Trotter, Medfield, MA (US);

Wonsuk Chang, Princeton, NJ (US);

Inventors:

Wen-Lian Wu, Green Brook, NJ (US);

Jongwon Lim, Lexington, MA (US);

Jared N. Cumming, Winchester, MA (US);

Benjamin Wesley Trotter, Medfield, MA (US);

Wonsuk Chang, Princeton, NJ (US);

Assignee:

Merck Sharp & Dohme LLC, Rahway, NJ (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/00 (2006.01); C07H 21/04 (2006.01); A61P 35/00 (2006.01); A61P 37/02 (2006.01); C07H 21/02 (2006.01);
U.S. Cl.
CPC ...
C07H 21/00 (2013.01); A61P 35/00 (2018.01); A61P 37/02 (2018.01); C07H 21/02 (2013.01); C07H 21/04 (2013.01);
Abstract

A class of polycyclic compounds of general formula (I), wherein Base, Base, Y, Y, X, X, X, X, X, X, X, X, R, R, R, R, R, R, R, R, R, R, R, R, R, R, and Rare defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds.


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