The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 11, 2022
Filed:
Apr. 08, 2020
Applicant:
President and Fellows of Harvard College, Cambridge, MA (US);
Inventors:
Andrew G. Myers, Boston, MA (US);
Ian Bass Seiple, San Francisco, CA (US);
Ziyang Zhang, San Francisco, CA (US);
Assignee:
President and Fellows of Harvard College, Cambridge, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 17/08 (2006.01); C07D 498/04 (2006.01); A61K 31/7048 (2006.01);
U.S. Cl.
CPC ...
C07H 17/08 (2013.01); A61K 31/7048 (2013.01); C07D 498/04 (2013.01);
Abstract
Provided herein are methods of preparing new 14-membered ketolides via coupling of an eastern and western half moiety, followed by macrocyclization, and optional functionalization. Intermediates in the synthesis of these ketolides including the eastern and western halves are also provided. Pharmaceutical compositions and methods of treating infectious diseases and inflammatory conditions using these ketolides are also provided.