The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 11, 2022
Filed:
Aug. 22, 2018
Tianjin Institute of Pharmaceutical Research Co., Ltd., Tianjin, CN;
Changjiang Huang, Tianjin, CN;
Shijun Zhang, Tianjin, CN;
Lingjun Li, Tianjin, CN;
Lei Liu, Tianjin, CN;
Yuquan Li, Tianjin, CN;
Jing Yuan, Tianjin, CN;
Hui Yan, Tianjin, CN;
Songhui Wang, Tianjin, CN;
Xuemin Zheng, Tianjin, CN;
Qunchao Wei, Tianjin, CN;
Xuyuan Liu, Tianjin, CN;
Wei Wei, Tianjin, CN;
Weiren Xu, Tianjin, CN;
Lida Tang, Tianjin, CN;
Meixiang Zou, Tianjin, CN;
TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH CO., LTD., Tianjin, CN;
Abstract
The present invention provides a compound having a structure of formula (I), a preparation method and use thereof, and a pharmaceutical composition containing the compound, wherein R is methyl, ethyl, propyl, vinyl or propenyl. The present invention also provides a crystalline form of the compound, a preparation method and use of the crystalline form, and a pharmaceutical composition comprising the crystalline form. The compounds having the structure of formula (I) of the present invention are present in a solid form, which not only can solve the problem of clopidogrel resistance, but also can solve the problem of severe hemorrhagic side effect and poor safety of some drugs, as well as the problem of poor stability of existing compounds. It can be developed into an ADP receptor antagonist antiplatelet agent with clear therapeutic effect, no resistance and better stability.