The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 11, 2022

Filed:

Mar. 01, 2019
Applicants:

Otsuka Pharmaceutical Co., Ltd., Tokyo, JP;

Taiho Pharmaceutical Co., Ltd., Tokyo, JP;

Inventors:

Christopher Norbert Johnson, Newport, GB;

Ildiko Maria Buck, London, GB;

Gianni Chessari, Cambridge, GB;

James Edward Harvey Day, Foxton, GB;

Hideto Fujiwara, Cambridge, GB;

Christopher Charles Frederick Hamlett, Cambridge, GB;

Steven Douglas Hiscock, Royston, GB;

Rhian Sara Holvey, Cambridge, GB;

Steven Howard, Cambridge, GB;

John Walter Liebeschuetz, Cambridge, GB;

Nicholas John Palmer, Cambridge, GB;

Jeffrey David St Denis, Waterbeach, GB;

David Geoffrey Twigg, Milton, GB;

Andrew James Woodhead, Histon, GB;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 487/04 (2006.01); A61K 31/4985 (2006.01); A61K 31/517 (2006.01); A61K 31/5377 (2006.01); A61K 45/06 (2006.01); C07D 519/00 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01); A61K 31/4985 (2013.01); A61K 31/517 (2013.01); A61K 31/5377 (2013.01); A61K 45/06 (2013.01); C07D 519/00 (2013.01); C07B 2200/07 (2013.01);
Abstract

The invention provides new pyrazine derivatives of formula (I): or a tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the substituents are as defined herein. The invention also provides pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.


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