The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 11, 2022

Filed:

Jul. 08, 2020
Applicant:

Imperial College Innovations Limited, London, GB;

Inventors:

Andrew Simon Bell, London, GB;

Edward William Tate, London, GB;

Robin John Leatherbarrow, London, GB;

Jennie Ann Hutton, London, GB;

James Antony Brannigan, York, GB;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 487/04 (2006.01); C07D 403/12 (2006.01); C07D 231/56 (2006.01); C07D 401/12 (2006.01); C07D 471/04 (2006.01); C07D 417/12 (2006.01); A61P 31/18 (2006.01); A61P 33/06 (2006.01); A61P 3/10 (2006.01); A61P 31/16 (2006.01); A61P 35/00 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01); A61P 3/10 (2018.01); A61P 31/16 (2018.01); A61P 31/18 (2018.01); A61P 33/06 (2018.01); A61P 35/00 (2018.01); C07D 231/56 (2013.01); C07D 401/12 (2013.01); C07D 403/12 (2013.01); C07D 417/12 (2013.01); C07D 471/04 (2013.01);
Abstract

This invention provides compounds of formula (I) and salts thereof, which have activity as inhibitors of N-myristoyl transferase (NMT). The invention also relates to uses of such compounds as medicaments, in particular in the treatment of a disease or disorder in which inhibition of N-myristoyl transferase provides a therapeutic or prophylactic effect, including protozoan infections (such as malaria and leishmaniasis), viral infections (such as human rhinovirus and HIV), and hyperproliferative disorders (such as B-cell lymphoma).


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