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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11465992 B1

PDFFull Text
Date of Patent:
Oct. 11, 2022

Filed:

Jul. 04, 2018

Sulfonamide carboxamide compounds

Applicant:

Inflazome Limited, Dublin, IE;

Inventors:

Matthew Cooper, Cambridge, GB;

David Miller, Cambridge, GB;

Angus MacLeod, Cambridge, GB;

Jimmy Van Wiltenburg, Groningen, NL;

Stephen Thom, Nottingham, GB;

Stephen St-Gallay, Nottingham, GB;

Jonathan Shannon, Nottingham, GB;

Assignee:

INFLAZOME LIMITED, Dublin, IE;

Attorney:

Alston & Bird LLP

Primary Examiner:

Samantha L Shterengarts

Int. Cl.
CPC ...
C07D 409/04 (2006.01); C07D 205/04 (2006.01); C07D 205/12 (2006.01); C07D 207/12 (2006.01); C07D 211/54 (2006.01); C07D 211/96 (2006.01); C07D 215/36 (2006.01); C07D 223/06 (2006.01); C07D 239/60 (2006.01); C07D 241/18 (2006.01); C07D 401/04 (2006.01); C07D 401/06 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01); C07D 405/04 (2006.01); C07D 405/06 (2006.01); C07D 453/02 (2006.01); C07D 471/08 (2006.01);
U.S. Cl.
CPC ...
C07D 409/04 (2013.01); C07D 205/04 (2013.01); C07D 205/12 (2013.01); C07D 207/12 (2013.01); C07D 211/54 (2013.01); C07D 211/96 (2013.01); C07D 215/36 (2013.01); C07D 223/06 (2013.01); C07D 239/60 (2013.01); C07D 241/18 (2013.01); C07D 401/04 (2013.01); C07D 401/06 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 405/04 (2013.01); C07D 405/06 (2013.01); C07D 453/02 (2013.01); C07D 471/08 (2013.01);
Abstract

The present invention relates to compounds of formula (I): wherein Q is selected from O or S; Ris a non-aromatic heterocyclic group comprising at least one ring nitrogen atom, wherein Ris attached to the sulfur atom of the sulfonylurea group by a ring carbon atom, and wherein Rmay optionally be substituted; and Ris a cyclic group substituted at the α-position, wherein Rmay optionally be further substituted. The present invention further relates to salts, solvates and prodrugs of such compounds, to pharmaceutical compositions comprising such compounds, and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by the inhibition of NLRP3.

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