IDiyas

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11465989 B1

PDFFull Text
Date of Patent:
Oct. 11, 2022

Filed:

Apr. 17, 2015

Guanidine compounds and use thereof

Applicant:

Immunomet Therapeutics Inc., Houston, TX (US);

Inventors:

Sung Wuk Kim, Seongnam-si, KR;

Hong Woo Kim, Daejeon, KR;

Sang Hee Yoo, Daejeon, KR;

Ji Sun Lee, Daejeon, KR;

Hye Jin Heo, Daejeon, KR;

Hong Bum Lee, Daejeon, KR;

Ji Ae Kook, Daejeon, KR;

Young Woo Lee, Daejeon, KR;

Mi Jeong Kim, Seoul, KR;

Woong Cho, Seongnam-si, KR;

Assignee:

ImmunoMet Therapeutics, Inc., Houston, TX (US);

Attorney:

Clark & Elbing LLP

Primary Examiner:

Sun Jae Yoo

Int. Cl.
CPC ...
C07D 295/13 (2006.01); C07D 213/38 (2006.01); C07D 213/40 (2006.01); C07D 333/20 (2006.01); C07D 333/16 (2006.01); C07D 249/14 (2006.01); C07D 251/18 (2006.01); C07D 251/48 (2006.01); C07D 211/14 (2006.01); C07D 211/54 (2006.01); C07D 209/44 (2006.01); C07D 209/40 (2006.01); C07D 233/88 (2006.01); C07D 233/91 (2006.01); C07D 207/46 (2006.01); C07D 279/08 (2006.01); C07D 203/12 (2006.01); C07D 239/42 (2006.01); C07D 263/48 (2006.01); C07D 319/18 (2006.01); C07D 317/58 (2006.01); C07D 277/46 (2006.01); A61P 3/00 (2006.01); A61P 3/04 (2006.01); A61P 3/10 (2006.01); A61P 3/06 (2006.01); A61P 5/50 (2006.01); A61P 13/00 (2006.01); A61P 21/00 (2006.01); A61P 35/00 (2006.01); A61P 35/04 (2006.01); A61P 9/00 (2006.01); A61P 19/10 (2006.01); A61P 1/16 (2006.01); A61P 15/00 (2006.01); C07C 279/16 (2006.01); C07C 311/47 (2006.01); C07C 311/49 (2006.01); C07C 279/12 (2006.01); C07C 279/26 (2006.01); C07C 279/24 (2006.01); C07C 279/08 (2006.01); C07C 279/04 (2006.01); C07C 279/06 (2006.01); C07D 403/12 (2006.01); C07D 207/16 (2006.01);
U.S. Cl.
CPC ...
C07D 403/12 (2013.01); C07C 279/04 (2013.01); C07C 279/06 (2013.01); C07C 279/08 (2013.01); C07C 279/12 (2013.01); C07C 279/16 (2013.01); C07C 279/24 (2013.01); C07C 279/26 (2013.01); C07C 311/47 (2013.01); C07C 311/49 (2013.01); C07D 207/16 (2013.01); C07D 209/40 (2013.01); C07D 209/44 (2013.01); C07D 211/14 (2013.01); C07D 211/54 (2013.01); C07D 213/38 (2013.01); C07D 213/40 (2013.01); C07D 233/88 (2013.01); C07D 233/91 (2013.01); C07D 239/42 (2013.01); C07D 249/14 (2013.01); C07D 251/18 (2013.01); C07D 251/48 (2013.01); C07D 263/48 (2013.01); C07D 277/46 (2013.01); C07D 295/13 (2013.01); C07D 317/58 (2013.01); C07D 319/18 (2013.01); C07D 333/16 (2013.01); C07D 333/20 (2013.01); C07C 2601/02 (2017.05); C07C 2601/04 (2017.05); C07C 2601/08 (2017.05); C07C 2601/14 (2017.05); C07C 2602/08 (2017.05); C07C 2602/10 (2017.05); C07C 2603/74 (2017.05);
Abstract

The present invention relates to guanidine compounds for inhibiting mitochondrial oxidative phosphorylation (OXPHOS) and use thereof. More specifically, the present invention relates to a pharmaceutical composition for preventing or treating a OXPHOS-related disease, particularly cancer, by inhibiting mitochondrial oxidative phosphorylation and reprogramming cellular metabolism.

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