The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 11, 2022
Filed:
Dec. 20, 2019
Applicant:
University of Massachusetts, Boston, MA (US);
Inventors:
Phillip D. Zamore, Northboro, MA (US);
Jennifer Broderick, Worcester, MA (US);
Assignee:
UNIVERSITY OF MASSACHUSETTS, Boston, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/11 (2006.01); A61K 48/00 (2006.01); C12N 15/113 (2010.01); C12N 15/115 (2010.01);
U.S. Cl.
CPC ...
A61K 48/0058 (2013.01); C12N 15/111 (2013.01); C12N 15/113 (2013.01); C12N 15/115 (2013.01); C12N 2310/11 (2013.01); C12N 2310/113 (2013.01); C12N 2310/16 (2013.01); C12N 2310/315 (2013.01); C12N 2310/3519 (2013.01); C12N 2320/30 (2013.01); C12N 2320/31 (2013.01); C12N 2320/32 (2013.01); C12N 2320/51 (2013.01); C12N 2320/53 (2013.01); C12N 2330/10 (2013.01); C12Q 2600/178 (2013.01);
Abstract
The instant disclosure provides RNA-modulating agents that function to recruit one or more small regulatory RNA molecules (e.g., miRNA molecules, Y RNAs, and siRNAs) to a target mRNA thereby modulating (e.g., inhibiting) the translation of the target mRNA or destabilizing the mRNA. Also provided are miRNA inhibitors and diagnostic agents that have improved binding affinity for their target miRNAs. Methods for using the RNA-modulating agents, miRNA inhibitors and diagnostic agents are also provided.