The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 11, 2022
Filed:
May. 02, 2017
Applicant:
Biodynamic Research Foundation, Kumamoto, JP;
Inventors:
Hiroshi Maeda, Kumamoto, JP;
Jun Fang, Kumamoto, JP;
Assignee:
BIODYNAMIC RESEARCH FOUNDATION, Kumamoto, JP;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 47/12 (2006.01); A61K 31/351 (2006.01); A61K 47/18 (2017.01); A61K 47/50 (2017.01); A61K 9/08 (2006.01); A61K 47/58 (2017.01); A61P 35/00 (2006.01); A61K 9/00 (2006.01); A61K 47/02 (2006.01); A61K 47/32 (2006.01); A61K 47/60 (2017.01); A61K 47/10 (2017.01); A61K 47/24 (2006.01); A61K 47/26 (2006.01); A61K 47/36 (2006.01); A61K 47/42 (2017.01); A61K 31/555 (2006.01); A61K 9/14 (2006.01);
U.S. Cl.
CPC ...
A61K 47/60 (2017.08); A61K 9/0019 (2013.01); A61K 9/08 (2013.01); A61K 9/14 (2013.01); A61K 31/351 (2013.01); A61K 31/555 (2013.01); A61K 47/02 (2013.01); A61K 47/10 (2013.01); A61K 47/12 (2013.01); A61K 47/18 (2013.01); A61K 47/183 (2013.01); A61K 47/24 (2013.01); A61K 47/26 (2013.01); A61K 47/32 (2013.01); A61K 47/36 (2013.01); A61K 47/42 (2013.01); A61K 47/50 (2017.08); A61K 47/58 (2017.08); A61P 35/00 (2018.01);
Abstract
The present invention provides a formulation having excellent solubility and/or stability of a macromolecular drug, and more specifically, a pharmaceutical composition containing a macromolecular drug, a dissolution-enhancing and/or stabilizing agent, and an aqueous solvent, wherein the dissolution-enhancing and/or stabilizing agent is at least one selected from the group consisting of (1) proteins, (2) synthetic polymers, (3) sugars or sugar alcohols, (4) inorganic salts, (5) amino acids, (6) phospholipids, (7) aliphatic alcohols, (8) medium-chain fatty acids, and (9) mucopolysaccharides.