The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 04, 2022
Filed:
Oct. 21, 2016
Integrated Dna Technologies, Inc., Coralville, IA (US);
Michael Allen Collingwood, North Liberty, IA (US);
Ashley Mae Jacobi, Tiffin, IA (US);
Garrett Richard Rettig, Coralville, IA (US);
Mollie Sue Schubert, Cedar Rapids, IA (US);
Mark Aaron Behlke, Coralville, IA (US);
INTEGRATED DNA TECHNOLOGIES, INC., Coralville, IA (US);
Abstract
This invention pertains to modified compositions for use in CRISPR systems, and their methods of use. In particular, length-modified and chemically-modified forms of crRNA and tracrRNA are described for use as a reconstituted guide RNA for interaction with Cas9 of CRISPR systems. The resultant length-modified and chemically-modified forms of crRNA and tracrRNA are economical to produce and can be tailored to have unique properties relevant to their biochemical and biological activity in the context of the CRISPR Cas9 endonuclease system.