The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 04, 2022
Filed:
Jul. 27, 2018
China Fortune Way Company, Beijing, CN;
Nanjing Redwood Fine Chemical Co., Ltd, Jiangsu, CN;
Fahao Wu, Nanjing, CN;
Wen Yang, Beijing, CN;
Gang Li, Nanjing, CN;
Hongwei Shi, Beijing, CN;
Yangzhe Gao, Nanjing, CN;
Lili Liu, Beijing, CN;
Zhifa Yuan, Beijing, CN;
China Fortune Way Company, Beijing, CN;
Nanjing Redwood Fine Chemical Co., Ltd., Nanjing, CN;
Abstract
Provided is a method for biocatalytic synthesis of Sitagliptin and intermediates thereof, in particular, provided are compounds of Formula (I) and Formula (II), or pharmaceutically acceptable salts thereof, a polypeptide capable of catalyzing conversion of a compound of Formula (I) to a compound of Formula (II), a nucleic acid encoding the polypeptide, a vector and a cell comprising the nucleic acid. In addition, also provided are a method for producing a compound of Formula (II) and Sitagliptin by using the polypeptide and the compound of Formula (I), and a method for preparing the polypeptide.