The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 04, 2022
Filed:
Dec. 28, 2016
Applicant:
Massachusetts Institute of Technology, Cambridge, MA (US);
Inventors:
Ram Sasisekharan, Lexington, MA (US);
Kannan Tharakaraman, Arlington, MA (US);
Vidya Subramanian, Concord, MA (US);
Eduardo Fleischer, North Miami Beach, FL (US);
Andrew Peter Hatas, Cambridge, MA (US);
Assignee:
Massachusetts Institute of Technology, Cambridge, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/46 (2006.01); C07K 16/22 (2006.01); C07K 16/32 (2006.01); C07K 16/28 (2006.01);
U.S. Cl.
CPC ...
C07K 16/468 (2013.01); C07K 16/22 (2013.01); C07K 16/2863 (2013.01); C07K 16/2887 (2013.01); C07K 16/2896 (2013.01); C07K 16/32 (2013.01); C07K 16/2818 (2013.01); C07K 2317/24 (2013.01); C07K 2317/31 (2013.01); C07K 2317/515 (2013.01); C07K 2317/522 (2013.01); C07K 2317/526 (2013.01); C07K 2317/55 (2013.01); C07K 2317/92 (2013.01);
Abstract
Described herein are mutations in the CH1/CL interface and CH3 constant regions of a bispecific antibody which facilitate heterodimerization and methods for the efficient production of bispecific antibodies. Also disclosed are therapeutic and diagnostic methods for using the antibodies.