The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 04, 2022
Filed:
Mar. 06, 2015
Applicant:
Proda Biotech Llc, Marietta, GA (US);
Inventor:
Zhi-Ren Liu, Marietta, GA (US);
Assignee:
ProDa Biotech LLC, Marietta, GA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 19/00 (2006.01); C07K 14/47 (2006.01); A61K 47/55 (2017.01); A61K 47/60 (2017.01); A61K 47/54 (2017.01); A61K 31/282 (2006.01); A61K 38/17 (2006.01); A61K 49/00 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/4728 (2013.01); A61K 31/282 (2013.01); A61K 38/1738 (2013.01); A61K 38/1761 (2013.01); A61K 47/545 (2017.08); A61K 47/551 (2017.08); A61K 47/60 (2017.08); A61K 49/0002 (2013.01); C07K 14/47 (2013.01); C07K 14/4747 (2013.01); A61K 38/00 (2013.01); C07K 2319/00 (2013.01);
Abstract
Therapeutic proteins for inducing apoptosis in cells and method for using such proteins are described. The protein, e.g., a chimeric protein, has a host peptide fused to a more stable BH3 domain peptide. The host peptide may be Calbindin D9k, a N-terminal or C-terminal half-domain of Calmodulin, Parvalbimin ('Pa'), an amino acid sequence variant thereof, or a modified variant thereof. The BH3 domain may be Bim, Bid, Bad, Bik, Bmf, Hrk, Puma, or Noxia. Moreover, various conjugates may be attached to the chimeric protein, including a folate and polyethylene glycol.