The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 04, 2022
Filed:
Mar. 25, 2020
Applicant:
Scinopharm Taiwan, Ltd., Tainan, TW;
Inventors:
Assignee:
ScinoPharm Taiwan, Ltd., Tainan, TW;
Primary Examiner:
Int. Cl.
CPC ...
C07K 1/20 (2006.01); C07K 14/605 (2006.01);
U.S. Cl.
CPC ...
C07K 1/20 (2013.01); C07K 14/605 (2013.01);
Abstract
The present invention provides improved processes for purifying liraglutide. Liraglutide is purified via two sequential RP-HPLC purifications followed by a salt-exchange step, where a pH is kept constant in the first and second purification steps. In particular, the processes utilize a halogenated solvent in a sample preparation step, which provides better solubility and an environment suitable for decarboxylation for crude liraglutide prior to a RP-HPLC purification.