The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 04, 2022
Filed:
Oct. 05, 2017
University of Maryland, Baltimore, Baltimore, MD (US);
Mcdaniel College, Westminster, MD (US);
Ashkan Emadi, Clarksville, MD (US);
Rena G. Lapidus, Baltimore, MD (US);
Brandon A. Carter-Cooper, Manchester, MD (US);
Steven Fletcher, Baltimore, MD (US);
Dana Ferraris, Eldersburg, MD (US);
Edward A. Sausville, Edgewater, MD (US);
UNIVERSITY OF MARYLAND, BALTIMORE, Baltimore, MD (US);
MCDANIEL COLLEGE, Westminster, MD (US);
Abstract
The invention relates to new amino dimeric naphthoquinone compounds with antileukemic activity. Compounds of the invention demonstrated increased aqueous solubility compared to previously available dimeric naphthoquinones and potent nanomolar inhibition of cell survival in AML cells. Preferred compounds contained an aziridine or a secondary amino alcohol pharmacophore.