The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 04, 2022
Filed:
Aug. 03, 2020
Applicant:
Pharmakea, Inc., San Diego, CA (US);
Inventors:
David Lonergan, San Diego, CA (US);
Kevin Ross Holme, San Diego, CA (US);
Martin W. Rowbottom, San Diego, CA (US);
Assignee:
PHARMAKEA, INC., San Diego, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 401/12 (2006.01); C07D 207/12 (2006.01); A61K 31/4439 (2006.01); C07C 309/66 (2006.01);
U.S. Cl.
CPC ...
C07D 401/12 (2013.01); A61K 31/4439 (2013.01); C07C 309/66 (2013.01); C07D 207/12 (2013.01); C07B 2200/13 (2013.01);
Abstract
Described herein are crystalline forms of pharmaceutically acceptable salts of the lysyl oxidase-like 2 (LOXL2) inhibitor (3-(4-(aminomethyl)-6-(trifluoromethyl)pyridin-2-yloxy)phenyl)((3R,4R)-3-fluoro-4-hydroxypyrrolidin-1-yl)methanone. Also described are methods of making the LOXL2 inhibitor, pharmaceutical compositions and medicaments comprising the LOXL2 inhibitor, and methods of using the LOXL2 inhibitor in the treatment of conditions, diseases, or disorders associated with LOXL2 activity.