The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 04, 2022
Filed:
Dec. 05, 2017
Microbiotix, Inc., Worcester, MA (US);
Albert Einstein College of Medicine, Inc., Bronx, NY (US);
The Government of the United States As Represented BY the Secretary of the Army, Fort Detrick, MD (US);
Terry L. Bowlin, Maineville, OH (US);
Donald T. Moir, Concord, MA (US);
Kartik Chandran, Brooklyn, NY (US);
John M. Dye, Jr., Frederick, MD (US);
John D. Williams, Fulton, MD (US);
Zachary D. Aron, Acton, MA (US);
Jay P. Barbor, Worcester, MA (US);
Kelly N. Lively, Holliston, MA (US);
Peter J. Nash, Newton, MA (US);
Debra M. Mills, Francestown, NH (US);
Arnab Basu, Acton, MA (US);
Microbiotix, Inc., Worcester, MA (US);
Albert Einstein College of Medicine, Bronx, NY (US);
The Government of the United States as Represented by the Secretary of the Army, Washington, DC (US);
Abstract
The present invention is related to the development of therapeutics and prophylactics for the treatment and/or prevention of filovirus infection in humans and other mammals. A new class of small molecules is disclosed that inhibits the interaction of naturally processed (i.e., proteolytically cleaved) filovirus glycoprotein (GP) with its host receptor Niemann-Pick C1 (NPC1) protein and thus block infection of host cells by filoviruses. Also disclosed are methods of using the small molecule inhibitors in the treatment/prevention of filovirus infection.