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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11459295 B1

PDFFull Text
Date of Patent:
Oct. 04, 2022

Filed:

Oct. 21, 2016

2-beta-naphthyl-acetic acid analogs as akr1c3 inhibitors and methods of using same

Applicants:

The Trustees of the University of Pennsylvania, Philadelphia, PA (US);

Vanderbilt University, Nashville, TN (US);

Inventors:

Trevor M. Penning, Springfield, PA (US);

Adegoke Adeniji, Richmond Hill, GA (US);

Lawrence J. Marnett, Nashville, TN (US);

Assignees:

THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, Philadelphia, PA (US);

VANDERBILT UNIVERSITY, Nashville, TN (US);

Attorneys:

Saul Ewing Arnstein & Lehr LLP

Domingos J. Silva

Primary Examiner:

Amanda L Aguirre

Int. Cl.
CPC ...
A61K 31/405 (2006.01); A61K 31/4166 (2006.01); A61K 31/506 (2006.01); A61K 31/52 (2006.01); A61K 31/573 (2006.01); A61K 45/06 (2006.01); A61P 35/00 (2006.01); C07C 57/40 (2006.01); C07C 311/51 (2006.01); C07C 317/44 (2006.01); C07C 323/62 (2006.01); C07C 59/64 (2006.01); A61K 31/192 (2006.01); A61K 31/131 (2006.01); A61K 31/16 (2006.01); A61K 31/337 (2006.01);
U.S. Cl.
CPC ...
C07C 311/51 (2013.01); A61K 31/192 (2013.01); A61K 45/06 (2013.01); A61P 35/00 (2018.01); C07C 57/40 (2013.01); C07C 59/64 (2013.01); C07C 317/44 (2013.01); C07C 323/62 (2013.01); A61K 31/131 (2013.01); A61K 31/16 (2013.01); A61K 31/337 (2013.01); A61K 31/405 (2013.01); A61K 31/4166 (2013.01); A61K 31/506 (2013.01); A61K 31/52 (2013.01); A61K 31/573 (2013.01); A61K 2300/00 (2013.01);
Abstract

The invention includes 2-β-naphthyl-acetic acid derivatives, which are selective AKR1C3 inhibitors. In certain embodiments, the compounds of the invention are (R)-naproxen analogs. The invention further includes methods of treating cancer, such as prostate cancer and/or castration-resistant prostate cancer, using at least one compound of the invention.

Find Patent Forward Citations

Penning, Trevor. (2022). 2-beta-naphthyl-acetic acid analogs as akr1c3 inhibitors and methods of using same (U.S. Patent No. 11459295). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11459295

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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