The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 04, 2022
Filed:
Dec. 08, 2021
Fred Hutchinson Cancer Center, Seattle, WA (US);
Rachel Perret, Wellington, NZ;
Philip D. Greenberg, Mercer Island, WA (US);
Thomas M. Schmitt, Seattle, WA (US);
Aude G. Chapuis, Seattle, WA (US);
Ingunn M. Stromnes, Minneapolis, MN (US);
Tijana Martinov, Seattle, WA (US);
FRED HUTCHINSON CANCER CENTER, Seattle, WA (US);
Abstract
The present disclosure provides compositions and methods for targeting a Ras antigen to, for example, treat or prevent cancer. Disclosed embodiments include binding proteins, such as a T cell receptor or a chimeric antigen receptor, that bind to a Ras antigen:HLA complex. Polynucleotides encoding such binding protein can introduced into a host cell, such as a T cell, and the cell can be used in immunotherapy for treating various cancers. Also provided are immunogenic polypeptides that can be useful to, for example, induce an immune response against a mutated Ras or to identify a binding protein that binds to a Ras antigen.