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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11458138 B1

PDFFull Text
Date of Patent:
Oct. 04, 2022

Filed:

Apr. 26, 2018

6-6 fused bicyclic heteroaryl compounds and their use as lats inhibitors

Applicant:

Novartis Ag, Basel, CH;

Inventors:

Dirk Behnke, Basel, CH;

Frada Berenshteyn, Woburn, MA (US);

Xueshi Hao, San Diego, CA (US);

Timothy Hoffman, San Diego, CA (US);

Qihui Jin, San Diego, CA (US);

Arnaud Lacoste, Cambridge, MA (US);

Cameron Lee, Cambridge, MA (US);

Jun Liu, San Diego, CA (US);

Yahu Liu, San Diego, CA (US);

Juergen Klaus Maibaum, Basel, CH;

Tingting Mo, Saratoga, CA (US);

Jianfeng Pan, San Diego, CA (US);

Xin Qu, Cambridge, MA (US);

Jan Tchorz, Basel, CH;

Yun Feng Xie, San Diego, CA (US);

Shanshan Yan, San Diego, CA (US);

Yefen Zou, San Diego, CA (US);

Assignee:

Novartis AG, Basel, CH;

Attorney:

Asha K. Nadipuram

Primary Examiner:

Timothy P Thomas

Int. Cl.
CPC ...
A61K 31/4375 (2006.01); A61K 31/519 (2006.01); C07D 487/04 (2006.01); C12N 5/079 (2010.01); C07D 519/00 (2006.01); A61P 17/02 (2006.01); A61K 9/00 (2006.01); A61K 31/47 (2006.01); A61K 31/506 (2006.01); A61K 35/30 (2015.01); C12N 15/52 (2006.01); C12N 15/864 (2006.01);
U.S. Cl.
CPC ...
A61K 31/519 (2013.01); A61K 9/0048 (2013.01); A61K 31/4375 (2013.01); A61K 31/47 (2013.01); A61K 31/506 (2013.01); A61P 17/02 (2018.01); C07D 487/04 (2013.01); C07D 519/00 (2013.01); C12N 5/0621 (2013.01); A61K 35/30 (2013.01); C12N 15/52 (2013.01); C12N 15/8645 (2013.01); C12N 2310/20 (2017.05); C12N 2502/085 (2013.01); C12N 2502/1352 (2013.01); C12N 2502/27 (2013.01);
Abstract

The present invention is related to 6-6 Fused Bicyclic Heteroaryl Compounds of the Formula A2 or A1 and their Use as LATS Inhibitors, or a salt, stereoisomer or pharmaceutical composition thereof; wherein the variables are as defined herein. The present invention further relates to a method of LATS inhibition in a cell population using a compound of Formula A1, or a salt, stereoisomer or pharmaceutical composition thereof. The present invention further provides a method for manufacturing compounds of the invention, and its therapeutic uses. The invention further provides methods to their preparation, to their medical use, their use in the treatment and management of diseases or disorders.

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