The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 04, 2022

Filed:

Nov. 24, 2010
Applicants:

Hanlan Liu, Lexington, MA (US);

Chris Willis, Southborough, MA (US);

Renu Bhardwaj, Ashland, MA (US);

Jianmei Kochling, Wellesley, MA (US);

Craig Siegel, Woburn, MA (US);

Inventors:

Hanlan Liu, Lexington, MA (US);

Chris Willis, Southborough, MA (US);

Renu Bhardwaj, Ashland, MA (US);

Jianmei Kochling, Wellesley, MA (US);

Craig Siegel, Woburn, MA (US);

Assignee:

GENZYME CORPORATION, Cambridge, MA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/4025 (2006.01); C07D 405/06 (2006.01); A61K 45/06 (2006.01); C07D 319/16 (2006.01);
U.S. Cl.
CPC ...
A61K 31/4025 (2013.01); A61K 45/06 (2013.01); C07D 319/16 (2013.01); C07D 405/06 (2013.01);
Abstract

The hemitartrate salt of a compound represented by the following structural formula: (Formula I Hemitartrate), which may be used in pharmaceutical applications, are disclosed. Particular single crystalline forms of the Formula (I) Hemitartrate are characterized by a variety of properties and physical measurements. As well, methods of producing crystalline Formula (I) Hemitartrate, and using it to inhibit glucosylceramide synthase or lowering glycosphingolipid concentrations in subjects to treat a number of diseases, are also discussed. Pharmaceutical compositions are also described.


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