The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 27, 2022
Filed:
Aug. 08, 2019
Applicant:
Immuneonco Biopharmaceuticals (Shanghai) Co., Ltd., Shanghai, CN;
Inventors:
Wenzhi Tian, Shanghai, CN;
Song Li, Shanghai, CN;
Assignee:
IMMUNEONCO BIOPHARMACEUTICALS (SHANGHAI) INC., Shanghai, CN;
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 16/32 (2006.01); C07K 14/705 (2006.01); A61P 35/00 (2006.01); A61K 39/00 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/32 (2013.01); A61P 35/00 (2018.01); C07K 14/70503 (2013.01); A61K 38/00 (2013.01); A61K 2039/505 (2013.01); C07K 2317/732 (2013.01); C07K 2319/00 (2013.01);
Abstract
The present disclosure provides a recombinant fusion protein containing an extracellular Ig-like domain of a signal-regulator protein (SIRP), linked via a linker, to a paratope of an Ig-like anti-HER2 antibody at the N-terminus of a heavy chain or a light chain constituting the paratope. The present disclosure also provides a polynucleotide encoding the recombinant fusion protein, an expression vector containing the polynucleotide, a method for producing the recombinant protein and a method for treating a disease caused by over-expression of CD47 and/or HER2.