The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 27, 2022
Filed:
May. 21, 2020
Werewolf Therapeutics, Inc., Cambridge, MA (US);
William Winston, West Newton, MA (US);
Daniel Hicklin, Montclair, NJ (US);
Vinay Bhaskar, San Francisco, CA (US);
Luke Evnin, San Francisco, CA (US);
Patrick Baeuerle, Gauting, DE;
Jose Andres Salmeron Garcia, Westminster, MA (US);
Heather Brodkin, West Newton, MA (US);
Cynthia Seidel-Dugan, Belmont, MA (US);
Werewolf Therapeutics, Inc., Cambridge, MA (US);
Abstract
The disclosure features fusion proteins that are conditionally active variants of IL-12. In one aspect, the full-length polypeptides of the invention have reduced or minimal cytokine-receptor activating activity even though they contain a functional cytokine polypeptide. Upon activation, e.g., by cleavage of a linker that joins a blocking moiety, e.g., a steric blocking polypeptide, in sequence to the active cytokine, the cytokine can bind its receptor and effect signaling.