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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11453666 B1

PDFFull Text
Date of Patent:
Sep. 27, 2022

Filed:

Mar. 20, 2020

Autotaxin inhibitory compounds

Applicant:

Cancer Research Technology Limited, London, GB;

Inventors:

Martin Lee Stockley, Cambridge, GB;

Ellen Catherine Macdonald, Cambridge, GB;

Pritom Shah, Cambridge, GB;

Allan Jordan, Manchester, GB;

James Hitchin, Manchester, GB;

Niall Hamilton, Manchester, GB;

Assignee:

Cancer Research Technology Limited, , GB;

Attorney:

Mintz Levin Cohn Ferris Glovsky and Popeo, P.C.

Primary Examiner:

Sun Jae Yoo

Int. Cl.
CPC ...
A61P 1/00 (2006.01); A61P 1/16 (2006.01); A61P 29/00 (2006.01); A61P 31/20 (2006.01); A61P 31/14 (2006.01); A61P 31/12 (2006.01); A61P 3/10 (2006.01); A61P 7/12 (2006.01); A61P 17/00 (2006.01); A61P 17/04 (2006.01); A61P 17/02 (2006.01); A61P 35/00 (2006.01); A61P 35/02 (2006.01); A61P 7/04 (2006.01); A61P 7/02 (2006.01); A61P 13/02 (2006.01); A61P 13/12 (2006.01); A61P 9/12 (2006.01); A61P 9/00 (2006.01); A61P 43/00 (2006.01); A61P 19/04 (2006.01); A61K 31/5025 (2006.01); A61K 31/444 (2006.01); A61K 31/4545 (2006.01); A61K 31/5377 (2006.01); A61K 31/404 (2006.01); A61K 31/551 (2006.01); A61K 31/55 (2006.01); A61K 31/496 (2006.01); A61K 31/4184 (2006.01); A61K 45/06 (2006.01); C07D 235/02 (2006.01); C07D 471/04 (2006.01); A61K 31/437 (2006.01);
U.S. Cl.
CPC ...
C07D 471/04 (2013.01); A61K 31/404 (2013.01); A61K 31/4184 (2013.01); A61K 31/437 (2013.01); A61K 31/444 (2013.01); A61K 31/4545 (2013.01); A61K 31/496 (2013.01); A61K 31/5025 (2013.01); A61K 31/5377 (2013.01); A61K 31/55 (2013.01); A61K 31/551 (2013.01); A61K 45/06 (2013.01); C07D 235/02 (2013.01);
Abstract

The present invention relates to compounds of formula I wherein A, A, A, R, R, R, R, R, R, L, Ar and Q are each as defined herein. The compounds of the present invention are inhibitors of autotaxin (ATX) enzyme activity. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions (e.g. fibrosis) in which ATX activity is implicated.

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