The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 27, 2022
Filed:
Nov. 12, 2018
Deutsches Krebsforschungszentrum, Heidelberg, DE;
Ruprecht-karls-universitaet Heidelberg, Heidelberg, DE;
Ann-Christin Eder, Simonswald, DE;
Matthias Eder, Simonswald, DE;
Klaus Kopka, Dresden, DE;
Martin Schaefer, Neckarsteinach, DE;
Ulrike Bauder-Wuest, Schriesheim, DE;
Uwe Haberkorn, Schwetzingen, DE;
Deutsches Krebsforschungszentrum, Heidelberg, DE;
Ruprecht-Karls-Universitaet Heidelberg, Heidelberg, DE;
Abstract
The present invention relates to a compound or a pharmaceutically acceptable salt thereof having a chemical structure comprising: A compound or a pharmaceutically acceptable salt thereof of formula (I): (A)-x-(B)-x-(C), wherein (A) is at least one motif specifically binding to cell membranes of neoplastic cells; (B) at least one chelator moiety of radiometals; (C) a dye moiety; xis a spacer covalently connecting (A) and (B); xis a spacer or a chemical single bond connecting (B) and (C); wherein (C) has the formula wherein Rto R, R, a, b, Y and Xto Xhave the meaning as indicated in the claims and description. The invention further relates to compositions comprising said compounds as well as a method for detecting neoplastic cells in a sample in vitro with the aid of the compounds or composition.