The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 27, 2022
Filed:
Jul. 10, 2019
Applicant:
Oncorus, Inc., Cambridge, MA (US);
Inventors:
Kenneth P. Greenberg, Cambridge, MA (US);
Mitchell H. Finer, Cambridge, MA (US);
Assignee:
Oncorus, Inc., Cambridge, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 35/763 (2015.01); A61P 35/00 (2006.01); C12N 15/113 (2010.01);
U.S. Cl.
CPC ...
A61K 35/763 (2013.01); A61P 35/00 (2018.01); C12N 15/113 (2013.01); C12N 15/1133 (2013.01); C12N 2310/113 (2013.01); C12N 2310/141 (2013.01); C12N 2320/30 (2013.01); C12N 2330/51 (2013.01); C12N 2710/16621 (2013.01); C12N 2710/16632 (2013.01); C12N 2710/16662 (2013.01);
Abstract
The present disclosure relates to recombinant viral vectors for the treatment and prevention of cancer. Oncolytic viral vectors incorporate one or more of the following features: viral replication restriction by insertion of tumor-suppressive microRNA (miRNA) target sequences into the viral genome; disruption of oncogenic miRNA function; cancer microenvironment remodeling; and cancer cell targeting by incorporation of protease-activated antibodies into the viral particle.