The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 27, 2022
Filed:
Mar. 12, 2014
Applicant:
Smith & Nephew, Inc., Memphis, TN (US);
Inventors:
Lei Shi, Mansfield, TX (US);
Aleksa Jovanovic, Fort Worth, TX (US);
Dennis Carson, Burleson, TX (US);
Assignee:
SMITH & NEPHEW, INC., Memphis, TN (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/70 (2006.01); A61L 15/44 (2006.01); A61L 15/60 (2006.01); A61L 15/28 (2006.01); A61L 15/38 (2006.01); A61L 15/62 (2006.01); A61K 38/48 (2006.01); A61K 47/10 (2017.01); A61K 47/38 (2006.01);
U.S. Cl.
CPC ...
A61K 9/7007 (2013.01); A61K 38/4873 (2013.01); A61K 38/4886 (2013.01); A61K 47/10 (2013.01); A61K 47/38 (2013.01); A61L 15/28 (2013.01); A61L 15/38 (2013.01); A61L 15/44 (2013.01); A61L 15/60 (2013.01); A61L 15/62 (2013.01); C12Y 304/22002 (2013.01); C12Y 304/24027 (2013.01);
Abstract
Disclosed is a dissolvable, gel-forming film, and methods for its use, comprising a water-soluble cellulose ether, a hydrophilic rheological modifying agent, and an active proteolytic enzyme or other drug substance. The gel-forming film has a water content of less than 15% w/w and is capable of forming a hydrogel when contacted with water or other aqueous medium. The disclosed films achieve delivery of stable proteolytic enzymes to the desired site of action in a manner that provides uniform delivery of the enzymes.