The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 20, 2022
Filed:
Feb. 28, 2019
Applicant:
President and Fellows of Harvard College, Cambridge, MA (US);
Inventors:
George M. Church, Brookline, MA (US);
Evan R. Daugharthy, Cambridge, MA (US);
Richard C. Terry, Carlisle, MA (US);
Assignee:
President and Fellows of Harvard College, Cambridge, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12P 19/34 (2006.01); C12N 15/10 (2006.01); C12Q 1/682 (2018.01); C12Q 1/6834 (2018.01); C12Q 1/6874 (2018.01); G01N 33/68 (2006.01); A61L 27/50 (2006.01);
U.S. Cl.
CPC ...
C12P 19/34 (2013.01); A61L 27/50 (2013.01); C12N 15/1093 (2013.01); C12Q 1/682 (2013.01); C12Q 1/6834 (2013.01); C12Q 1/6874 (2013.01); G01N 33/6842 (2013.01); A61L 2400/16 (2013.01); B01L 2300/0636 (2013.01);
Abstract
The present disclosure provides methods that combine RNA fluorescent in situ sequencing (FISSEQ) with other molecular detection modalities, forming an integrated panomic detection platform. In various embodiments, the present disclosure provides systems and methods to prepare a biological sample to preserve the spatial relationships of biomolecules of interest within the biological sample for FISSEQ detection.