logo

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11447768 B1

PDFFull Text
Date of Patent:
Sep. 20, 2022

Filed:

Mar. 01, 2017

Molecular cell diary system

Applicant:

University of Florida Research Foundation, Incorporated, Gainesville, FL (US);

Inventors:

David Tran, Gainesville, FL (US);

Son Le, Gainesville, FL (US);

Assignee:

University of Florida Research Foundation, Incorporated, Gainesville, FL (US);

Attorney:

Alston & Bird LLP

Primary Examiner:

Shin Lin Chen

Int. Cl.
CPC ...
A01N 63/00 (2020.01); C07H 21/04 (2006.01); C12N 15/10 (2006.01); C12N 15/85 (2006.01); C12N 15/90 (2006.01); A01K 67/027 (2006.01); C12N 15/63 (2006.01); C12N 9/12 (2006.01); C12N 9/22 (2006.01); C12Q 1/6886 (2018.01);
U.S. Cl.
CPC ...
C12N 15/1024 (2013.01); A01K 67/0275 (2013.01); C12N 9/1252 (2013.01); C12N 9/22 (2013.01); C12N 15/102 (2013.01); C12N 15/63 (2013.01); C12N 15/85 (2013.01); C12N 15/90 (2013.01); C12Q 1/6886 (2013.01); C12Y 207/07007 (2013.01); C12N 2800/80 (2013.01); G01N 2800/7028 (2013.01);
Abstract

The subject invention pertains to a Molecular Cell Diary System (MCDS), which allows identification of the history of somatic alterations in the cell. MCDS comprises one or more combinations of a DNA cutter and a DNA writer expressed under the control of a promoter controlled a cellular event of interest. The DNA cutter and the DNA writer are in a combination are co-expressed when an even of interest occurs. The DNA cutter creates double strand breaks (DSB) in a target DNA in a sequence specific manner and the DNA writer incorporates DNA sequences in the DSB. The endogenous DNA repair machinery synthesizes repairs the DSB. As such, the combination of the DNA cutter and the DNA writer modifies the target DNA and leaves 'marks' of the occurrence of the cellular event of interest. These marks are sequenced and the cellular event history of the cell is deciphered.

Find Patent Forward Citations

Tran, David. (2022). Molecular cell diary system (U.S. Patent No. 11447768). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11447768

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

Loading…