The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 20, 2022
Filed:
Nov. 16, 2018
Applicant:
Crage Medical Co., Limited, Kowloon, CN;
Inventors:
Zonghai Li, Shanghai, CN;
Peng Wang, Shanghai, CN;
Assignee:
CRAGE MEDICAL CO., LIMITED, Kowloon, CN;
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/395 (2006.01); A61K 39/00 (2006.01); C07K 16/40 (2006.01); C07K 19/00 (2006.01); C12N 15/62 (2006.01); C12N 15/86 (2006.01);
U.S. Cl.
CPC ...
C07K 16/40 (2013.01); C07K 19/00 (2013.01); C12N 15/62 (2013.01); C12N 15/86 (2013.01); A61K 2039/505 (2013.01); C07K 2317/565 (2013.01); C07K 2317/622 (2013.01);
Abstract
A binding unit that specifically binds to fibroblast activation protein α (FAPα), a polynucleotide that encodes the binding unit, a vector that comprises the polynucleotide and a host cell, a method for use in producing the antigen-binding unit and a method for treating a disease by using the FAPα-specific binding unit; the binding unit that specifically binds to FAPα may efficiently bind to tumor cells that express FAPα, and immune effector cells comprising the binding unit exhibit significant killing capabilities against tumor cells that express FAP.