The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11447522 B1

Date of Patent:

Sep. 20, 2022

Filed:

Jun. 13, 2018

Potent soft anti-inflammatory corticosteroid compounds and uses thereof

Applicant:

Bodor Laboratories, Inc., Miami, FL (US);

Inventor:

Nicholas S. Bodor, Bal Harbour, FL (US);

Assignee:

BODOR LABORATORIES, INC., Miami, FL (US);

Attorney:

Sheppard, Mullin, Richter & Hampton LLP

Primary Examiner:

John S Kenyon

Int. Cl.

CPC ...

C07J 7/00 (2006.01); A61P 27/02 (2006.01); A61P 29/00 (2006.01); A61K 9/00 (2006.01);

U.S. Cl.

CPC ...

C07J 7/009 (2013.01); A61K 9/0014 (2013.01); A61K 9/0048 (2013.01); A61P 27/02 (2018.01); A61P 29/00 (2018.01);

Abstract

Potent soft corticosteroid pharmaceutical compositions comprising them and method for use as anti-inflammatory agents. Also, a method for softening fluticasone propionate and similar corticosteroids to arrive at potent but safer alternatives. The compound 5-fluoromethyl 17α-dichloroacetoxy-6α,9α-difluoro-11β-hydroxy-16a-methyl-3-oxoandrosta-1,4-diene-17β-carbothioate, which is equally potent to but safer than fluticasone, is among those provided. Another compound of particular interest is 2-hydroxyethyl 17α-dichloroacetoxy-6α,9α-difluoro-11β-hydroxy-16β-methyl-3-oxoandrosta-1,4-diene-17β-carboxylate.

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