The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 20, 2022

Filed:

Aug. 16, 2017
Applicants:

Uwm Research Foundation, Inc., Milwaukee, WI (US);

The Trustees of Columbia University IN the City of New York, New York, NY (US);

Inventors:

Alexander E. Arnold, Milwaukee, WI (US);

Douglas C. Stafford, Stoughton, WI (US);

James M. Cook, Milwaukee, WI (US);

Charles W. Emala, Woodcliff Lake, NJ (US);

Gloria Forkuo, Milwaukee, WI (US);

Rajwana Jahan, Milwaukee, WI (US);

Revathi Kodali, Milwaukee, WI (US);

Guanguan Li, Milwaukee, WI (US);

Michael Rajesh Stephen, Milwaukee, WI (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/5517 (2006.01); C07D 487/04 (2006.01); C07D 487/14 (2006.01); A61P 11/06 (2006.01);
U.S. Cl.
CPC ...
C07D 487/14 (2013.01); A61P 11/06 (2018.01); C07D 487/04 (2013.01);
Abstract

Substituted benzo[f]imidazo[1,5-α][1,4]diazepines of formula (I') target alpha-4 and alpha-5 GABAreceptors for use in the treatment of airway hyperresponsiveness and inflammation in asthma. Compounds selectively partition to the peripheral compartment and have reduced CNS effects.


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