2-amino-benzimidazole derivatives and their use as 5-lipoxygenase and/or prostaglandin e synthase inhibitors

Abstract

The present invention relates to benzimidazole derivatives having the general formula I, wherein n is 0 or 1; Xand Xare independently, at each occurrence, CRor N; Y is C-Calkylene, wherein alkylene is optionally substituted with one to two C-Calkyl groups; Ris selected from the group consisting of hydrogen, halogen, C-Calkoxy, —NH, —NHR, —NRRand —NH—(R)—R, n being 0 or 1; Ris selected from the group consisting of hydrogen, halogen, C-Calkyl, —NH, —NHR, —NRRand —NH—(R)—R; Ris selected from the group consisting of hydrogen, hydroxyl, OR, —NRR, C-Calkoxy, C-Calkyl, C-Ccycloalkyl, C-Chaloalkyl, —C(O)NHR, aryl, heteroaryl and heterocyclyl, wherein each of said cycloalkyl, aryl, heteroaryl and heterocyclyl is optionally and independently substituted with one to four Rgroups; and Ris selected from the group consisting of —NH, —N(R)(V)R, —NH(V)—OR, —NHC(O)R, and groups of formula 1a shown below, and their use in the treatment of diseases, in particular inflammatory diseases, cancer, stroke and/or Alzheimer's disease.