The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 20, 2022
Filed:
Mar. 28, 2017
Piramal Pharma Limited, Mumbai, IN;
Milind Gharpure, Maharashtra, IN;
Ashutosh Jagtap, Maharashtra, IN;
Changdev Raut, Maharashtra, IN;
Nainesh Kansagara, Maharashtra, IN;
Jaisankar Krishnapillai, Tamilnadu, IN;
Nirmal Kumar Manoharan, Tamilnadu, IN;
Navnath Patil, Maharashtra, IN;
PIRAMAL PHARMA LIMITED, Mumbai, IN;
Abstract
The present invention provides an improved process for preparation of L-threo-(2S,3R)-3-(3,4-dihydroxyphenyl)serine (I) (Droxidopa) and its salts; comprising (a) reaction of the aldehyde compound (III) (as described herein) with Metal complex (II) (as described herein), and (h) hydrolysis of the compound (IV) obtained from step (a) in presence of acid. The present invention also relates to a novel intermediates metal chiral complex (IV) for the preparation of Droxidopa.