The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 20, 2022
Filed:
Jul. 14, 2021
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
Mark Greene, Penn Valley, PA (US);
Hongtao Zhang, Paoli, PA (US);
Hiromichi Tsuchiya, Philadelphia, PA (US);
Yasuhiro Nagai, Philadelphia, PA (US);
Lian Lam, Philadelphia, PA (US);
Aaron Runkle, Philadelphia, PA (US);
Jeffrey Drebin, Bryn Mawr, PA (US);
Mei Qing Ji, Voorhees, NJ (US);
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
Abstract
Disclosed herein are methods of increasing response to radiation therapy in subjects afflicted with cancer. In some embodiments, the method comprises reducing the ability of an immune suppressor cell (e.g., MDSC) to migrate to the microenvironment of the cancer. In some embodiments, the method further comprises suppressing the migration of the immune suppressor cell to a non-malignant cell and/or suppressing the malignant transformation of the non-malignant cells.