The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 20, 2022
Filed:
Aug. 09, 2018
Applicant:
The Board of Regents of the University of Oklahoma, Norman, OK (US);
Inventors:
Roger G. Harrison, Jr., Norman, OK (US);
Patrick H. McKernan, Norman, OK (US);
Assignee:
The Board of Regents of the University of Oklahoma, Norman, OK (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/51 (2006.01); A61K 47/60 (2017.01); A61K 45/06 (2006.01); C12N 9/88 (2006.01); A61K 31/223 (2006.01);
U.S. Cl.
CPC ...
A61K 38/51 (2013.01); A61K 45/06 (2013.01); A61K 47/60 (2017.08); C12N 9/88 (2013.01); A61K 31/223 (2013.01); C12Y 404/01001 (2013.01);
Abstract
A method, composition, and kit for treating a malarial infection in a subject by using an enzyme conjugate comprising a variant cystathione-gamma-lyase and a targeting ligand which binds to erythrocytes infected withpathogens. The variant cystathione-gamma-lyase has methioninase activity. Also disclosed is a method of treating-infected blood by exposing the infected blood with the enzyme conjugate.