The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 20, 2022
Filed:
Mar. 21, 2018
Applicant:
Consejo Superior DE Investigaciones Cientificas (Csic), Madrid, ES;
Inventors:
Ana Martinez Gil, Madrid, ES;
Daniel I. Perez, Madrid, ES;
Carmen Gil Ayuso-Gontán, Madrid, ES;
Angeles Martin-Requero, Madrid, ES;
Elisa Rojas Prats, Madrid, ES;
Loreto Martinez-Gonzalez, Madrid, ES;
Concepción Perez, Madrid, ES;
Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/52 (2006.01); A61P 25/28 (2006.01);
U.S. Cl.
CPC ...
A61K 31/52 (2013.01); A61P 25/28 (2018.01);
Abstract
The present invention relates to a series of substituted purine derivatives capable of inhibiting CDC7 kinase activity and, as such, suitable for use in the treatment of neurological diseases such as, inter alia, Alzheimer's disease, amyotrophic lateral sclerosis or frontotemporal dementia, involving hyperphosphorylation of TDP-43 and the subsequent formation of aggregates, induced by CDC7.