The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 20, 2022
Filed:
Jun. 15, 2021
Applicant:
Medimmune Limited, Cambridge, GB;
Inventors:
Philip Wilson Howard, Cambridge, GB;
Niall Dickinson, Cambridge, GB;
Thais Cailleau, Cambridge, GB;
Luke Masterson, Cambridge, GB;
William Goundry, Cambridge, GB;
Assignee:
MedImmune Limited, Cambridge, GB;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/4745 (2006.01); A61K 47/68 (2017.01); A61P 35/00 (2006.01); C07D 491/22 (2006.01); A61K 47/65 (2017.01); A61K 47/54 (2017.01);
U.S. Cl.
CPC ...
A61K 31/4745 (2013.01); A61K 47/545 (2017.08); A61K 47/65 (2017.08); A61K 47/6803 (2017.08); A61P 35/00 (2018.01); C07D 491/22 (2013.01);
Abstract
A conjugate comprising the following topoisomerase inhibitor derivative (A*): with a linker for connecting to a Ligand Unit, wherein the linker is attached in a cleavable manner to the amino residue. The Ligand Unit is preferably an antibody. Also provided is A* with the linking unit attached, and intermediates for their synthesis, as well as the released warhead.