The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 20, 2022

Filed:

Jun. 27, 2018
Applicant:

The Regents of the University of California, Oakland, CA (US);

Inventors:

Niren Murthy, Berkeley, CA (US);

Corinne Sadlowski, Berkeley, CA (US);

Bora Park, Berkeley, CA (US);

Assignee:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/381 (2006.01); A61P 31/04 (2006.01); A61K 31/10 (2006.01); A61K 31/4178 (2006.01); A61K 45/06 (2006.01); C07D 333/44 (2006.01);
U.S. Cl.
CPC ...
A61K 31/381 (2013.01); A61K 31/10 (2013.01); A61K 31/4178 (2013.01); A61K 45/06 (2013.01); A61P 31/04 (2018.01); C07D 333/44 (2013.01);
Abstract

Aspects of the present disclosure include antibacterial aromatic sulfonyl fluoride agents. The subject aromatic sulfonyl fluoride agents have a pharmacophore that can provide for potent antibacterial activity. The subject agents are compounds including an aromatic group substituted with a sulfonyl fluoride warhead group and an electron withdrawing group. The subject agents find use in a variety of antibiotic applications. In some cases, the subject agents find use in methods of treating bacterial infections in a subject. Also provided are pharmaceutical compositions and kits that find use in practicing the subject methods.


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