The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 20, 2022
Filed:
Sep. 27, 2016
Wayne State University, Detroit, MI (US);
The United States of America, As Represented BY the Secretary, Department of Health & Human Resources, Bethesda, MD (US);
Kannan Rangaramanujam, Detroit, MI (US);
Sujatha Kannan, Detroit, MI (US);
Roberto Romero, Grosse Point, MI (US);
Raghavendra Navath, Somerset, NJ (US);
Anupa Menjoge, New Hyde Park, NY (US);
Wayne State University, Detroit, MI (US);
The United States of America, as Represented by the Secretary, Department of Health and Human Services, Bethesda, MD (US);
Abstract
Injectable hydrogels in the form of crosslinked nano beads or particle in the size range 5 nm to 10 μm, comprising PAMAM dendrimer with asymmetrical peripheral end groups such that one of the terminal groups is involved in formation of hydrogel and the other in involved in the conjugation of drugs or imaging agents are formed by reaction of the PAMAM dendrimer with asymmetrical end groups with linear, branched, hyperbranched or star shaped polymers with functionalized terminal groups. The PAMAM dendrimer with asymmetrical terminal groups consists of a Generation 2 and above PAMAM dendrimer with symmetrical end groups modified using the amino acids or their modified forms. The gel is formed as small crosslinked particles in the size range 25 nm to 10 μm and is suitable for injectable delivery of hydrogel or ocular delivery for the purpose of therapeutic treatment and imaging.