The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 13, 2022
Filed:
Jan. 28, 2020
Xyphos Biosciences Inc., South San Francisco, CA (US);
The J. David Gladstone Institutes, a Testamentary Trust Established Under the Will of J. David gladstone, San Francisco, CA (US);
Kaman Kim, South San Francisco, CA (US);
Nigel Killeen, South San Francisco, CA (US);
Eytan Herzig, South San Francisco, CA (US);
Warner Greene, South San Francisco, CA (US);
Xyphos Biosciences Inc., South San Francisco, CA (US);
THE J. DAVID GLADSTONE INSTITUTES, San Francisco, CA (US);
Abstract
This application relates generally to the production of modified, non-natural α1-α2 domains of NKG2D ligands with attached polypeptides having specific target-binding properties, for example, antibodies or variable fragments of antibodies, that are selectively delivered to Chimeric Antigen Receptors (CARs) comprised of modified, non-natural NKG2D receptors on engineered mammalian cells. The targeting of surface-expressed molecules includes those of virus-infected cells that can then be attacked and ablated by engineered cells of the immunity system expressing CARs cognate to the modified, non-natural α1-α2 domains of NKG2D ligands with attached polypeptides.