The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 13, 2022

Filed:

Nov. 01, 2019
Applicant:

Showa University, Tokyo, JP;

Inventors:

Takashi Itoh, Tokyo, JP;

Kazuhiro Nagata, Tokyo, JP;

Takuya Kanemitsu, Tokyo, JP;

Michiko Miyazaki, Tokyo, JP;

Yuichiro Tomisawa, Tokyo, JP;

Misa Mori, Tokyo, JP;

Assignee:

SHOWA UNIVERSITY, Tokyo, JP;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 493/04 (2006.01); C07D 311/58 (2006.01); C07C 67/30 (2006.01); C07C 67/31 (2006.01);
U.S. Cl.
CPC ...
C07D 493/04 (2013.01); C07C 67/30 (2013.01); C07C 67/31 (2013.01); C07D 311/58 (2013.01);
Abstract

The present invention provides a compound having a dihydropyran structure, a method of producing a compound having a dihydropyran structure, a method of producing Pre-SMTP, a method of producing a group of SMTPs, and a pharmaceutical composition. The compound having a dihydropyran structure can be a useful intermediate in the chemically producing a group of Pre-SMTP and SMTP. Specifically, the compound having a dihydropyran structure is represented by the following formula (), wherein: RSi is a silyl group selected from TMS: trimethylsilyl, TES: triethysilyl, TBS (TBDMS): tert-butyldimethylsil, TIPS: triisopropylsilyl, TBDPS: tert-butyldiphenylsilyl, X is selected from COOH, CHO, and —CH═C(CH)—(CH)—CH═C(CH).


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