The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 13, 2022
Filed:
Aug. 27, 2018
Applicant:
Zhihong Chen, Lexington, MA (US);
Inventor:
Zhihong Chen, Lexington, MA (US);
Assignee:
Other;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 405/14 (2006.01); C07D 405/12 (2006.01); C07D 473/16 (2006.01); C07D 487/04 (2006.01); C07D 495/04 (2006.01);
U.S. Cl.
CPC ...
C07D 405/14 (2013.01); C07D 405/12 (2013.01); C07D 473/16 (2013.01); C07D 487/04 (2013.01); C07D 495/04 (2013.01);
Abstract
The invention provide novel pyrimidine derivatives and analogs having inhibitory activities towards certain tyrosine kinases, e.g., Bruton's tyrosine kinase (Btk) and/or Focal adhesion kinase (FAK), extracellular signal-regulated kinase (ERK), pharmaceutical compositions thereof, and methods of treatment, reduction or prevention of certain diseases or conditions mediated by such by tyrosine kinases, e.g., cancers, tumors, fibrosis, inflammatory diseases, autoimmune diseases, diabetes, or immunologically mediated diseases.